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Ezetimibe zetia is a selective cholesterol-absorption inhibitor that has been used as secondary therapy in the management of dyslipidemia, such as in the following clinical situations 39 .

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ZETIA has not been studied in Fredrickson Type IIIIIVand V dyslipidemias.

Concomitant food administrationhigh-fat or non-fat mealshad no effect on the extent of absorption of ezetimibe when administered as ZETIA 10-mg tabletsThe C value of ezetimibe was increased by 38with consumption of high-fat mealsZETIA can be administered with or without food.

In the ZETIAstatin controlled clinical trials database of 11,308 patients with a median treatment duration of 8 weeksrange 0 to 112 weeks4.0of patients on ZETIAstatin and 3.3of patients on statin alone discontinued due to adverse reactionsThe most common adverse reactions in the group of patients treated with ZETIAstatin that led to treatment discontinuation and occurred at a rate greater than statin alone were:

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Hypersensitivity reactionsincluding anaphylaxisangioedemarashand urticariaerythema multiformearthralgiamyalgiaelevated creatine phosphokinasemyopathy/rhabdomyolysissee WARNINGS AND PRECAUTIONSelevations in liver transaminaseshepatitisabdominal painthrombocytopeniapancreatitisnauseadizzinessparesthesiadepressionheadachecholelithiasischolecystitis.

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It is not known whether ezetimibe is excreted into human breast milkIn rat studiesexposure to total ezetimibe in nursing pups was up to half of that observed in maternal plasmaBecause many drugs are excreted in human milkcaution should be exercised when ZETIA is administered to a nursing womanZETIA should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

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