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It is not known whether Zetia alone will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnantUse effective birth control to prevent pregnancy while you are using ezetimibe with a statin medication.

EzetimibeZetiais a newly Food and Drug Administration(FDAapproved medication that selectively inhibits the intestinal absorption of cholesterol and related phytosterolsIt is approved for primary hypercholesterolemiaheterozygous familial and nonfamilial hypercholesterolemiaas monotherapy or in combination with 3-hydroxy-3-methylglutaryl coenzyme AHMG-CoAreductase inhibitorsstatinsIt is also indicated in combination with atorvastatin or simvastatin for homozygous familial hypercholesterolemia and as an adjunct to diet for homozygous sitosterolemia1

Take a missed dose as soon as you think about itIf it is close to the time for your next doseskip the missed dose and go back to your normal timeDo not take 2 doses at the same time or extra doses.

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Call your doctor right away if you have unexplained muscle paintendernessor weakness especially if you also have feverunusual tirednessand dark colored urine.

If you also take cholestyraminecolestipolor colesevelamWait at least 4 hours after taking any of these medicines before you take ezetimibeYou may also take ezetimibe 2 hours before taking any of these other medicines.

Avoid eating foods that are high in fat or cholesterolZetia will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Because clinical studies are conducted under widely varying conditionsadverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.

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ZETIA has not been studied in Fredrickson Type IIIIIVand V dyslipidemias.

Concomitant food administrationhigh-fat or non-fat mealshad no effect on the extent of absorption of ezetimibe when administered as ZETIA 10-mg tabletsThe C value of ezetimibe was increased by 38with consumption of high-fat mealsZETIA can be administered with or without food.

In the ZETIAstatin controlled clinical trials database of 11,308 patients with a median treatment duration of 8 weeksrange 0 to 112 weeks4.0of patients on ZETIAstatin and 3.3of patients on statin alone discontinued due to adverse reactionsThe most common adverse reactions in the group of patients treated with ZETIAstatin that led to treatment discontinuation and occurred at a rate greater than statin alone were:

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It is not known whether ezetimibe is excreted into human breast milkIn rat studiesexposure to total ezetimibe in nursing pups was up to half of that observed in maternal plasmaBecause many drugs are excreted in human milkcaution should be exercised when ZETIA is administered to a nursing womanZETIA should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

For High CholesterolFamilial HeterozygousI have been on Zetia for a number of yearsThe retail price has now gone over the one thousand dollar amount for a three month suppy12 for each tiny capsuleWhat is the dealMy drhas recently told me to take one every other day to cut the costI am on social security and have a good RX policybut it still costs me over5.50 in cashThat is prohibitive for a drug that has been on the market for years and yearsI think the makers of it are out of their mindsMy last refill the retail was899Please tell WHY has it gone up almost200

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to make sure you can safely use zetia, tell your doctor if you have any of these conditions any allergies to ezetimibe or other chemicals contained in zetia liver disease kidney disease thyroid disorder if you use steroid medicine or hormones including birth control pills pregnant or breast-feeding speak with your doctor about your individual risks and benefits.
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