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EzetimibeZetiais a newly Food and Drug Administration(FDAapproved medication that selectively inhibits the intestinal absorption of cholesterol and related phytosterolsIt is approved for primary hypercholesterolemiaheterozygous familial and nonfamilial hypercholesterolemiaas monotherapy or in combination with 3-hydroxy-3-methylglutaryl coenzyme AHMG-CoAreductase inhibitorsstatinsIt is also indicated in combination with atorvastatin or simvastatin for homozygous familial hypercholesterolemia and as an adjunct to diet for homozygous sitosterolemia1

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If you also take cholestyraminecolestipolor colesevelamWait at least 4 hours after taking any of these medicines before you take ezetimibeYou may also take ezetimibe 2 hours before taking any of these other medicines.

Avoid eating foods that are high in fat or cholesterolZetia will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Because clinical studies are conducted under widely varying conditionsadverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.

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Concomitant food administrationhigh-fat or non-fat mealshad no effect on the extent of absorption of ezetimibe when administered as ZETIA 10-mg tabletsThe C value of ezetimibe was increased by 38with consumption of high-fat mealsZETIA can be administered with or without food.

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It is not known whether ezetimibe is excreted into human breast milkIn rat studiesexposure to total ezetimibe in nursing pups was up to half of that observed in maternal plasmaBecause many drugs are excreted in human milkcaution should be exercised when ZETIA is administered to a nursing womanZETIA should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

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to make sure you can safely use zetia, tell your doctor if you have any of these conditions any allergies to ezetimibe or other chemicals contained in zetia liver disease kidney disease thyroid disorder if you use steroid medicine or hormones including birth control pills pregnant or breast-feeding speak with your doctor about your individual risks and benefits.
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